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Lack of antifibrotic efficacy of nintedanib in OP-bleo–induced pulmonary fibrosis. (A) Hydroxyproline content as fibrosis measurement. (B) Pressure–volume curve, (C) tissue elasticity, (D) tissue damping, and (E) FEV as a measure of lung function. n = 5 mice per group for control and 7 mice per vehicle and nintedanib-treated groups. *P < 0.05 indicates significant difference from vehicle-treated group. Ctrl = control; FEV = forced expiratory volume.
