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LPS-induced acute lung injury increased P-gp expression, but not BCRP expression, in mice. Gene expression of (A) inflammatory cytokines and chemokines and (B) fibrogenic markers. (C) HYP content. (D) Gene expression of drug efflux–associated ABC transporters. (E) Protein expression of P-gp and BCRP proteins with immunohistochemistry. Scale bar: 100 μm. n = 3 mice per group. *P < 0.05 indicates significant difference from the control group.
