Multiple sequence alignment of “Tryp_SPc domain” in SPs and SPHs. Multiple alignment was conducted using Clustal Omega and visualized by ESPript 3.0. Protein full names and sequence accession numbers are provided as follows. Pvin-SP29, P. vindemmiae serine protease homolog 29 precursor (Cluster-8535.6041); Pvin-SP33, P. vindemmiae serine protease 33 precursor (Cluster-8535.25017); Pvin-SP64, P. vindemmiae serine protease 64 precursor (Cluster-8535.6181); Ppup-SP87, P. puparum serine protease 87 precursor (comp43143_c1) (Yan et al., 2016); Nvit-SP64, N. vitripennis serine protease 64 precursor (NP_001166082.1); Nvit-Try2, N. vitripennis trypsin-2-like (XP_016843706.1); Nvit-SP27, N. vitripennis serine protease 33 precursor (NP_001155017.1); Nvit-Try3, N. vitripennis trypsin-3 (XP_001603705.2); Nvit-SP27P, N. vitripennis serine protease 27 precursor (NP_001166077.1); Nvit-SPH29, N. vitripennis serine protease homolog 29 precursor (NP_001155016.1); Nvit-Try7, N. vitripennis trypsin-7 (XP_016838732.1). Pvin-VAP, P. vindemmiae venom acid phosphatase (Cluster-8535.24978); Pvin-VAPA, P. vindemmiae venom acid phosphatase Acph-1-like (Cluster-8535.6129); Ppup-VAP, P. puparum venom acid phosphatase (ACA60733.1); Nvit-VAPP, N. vitripennis venom acid phosphatase-like precursor (NP_001155147.1); Nvit-VAPA1, N. vitripennis venom acid phosphatase Acph-1-like (XP_001605452.1); Nvit-VAPA1.1, N. vitripennis venom acid phosphatase Acph-1-like (XP_001600770.1); Lhet-VAPA1.1, L. heterotoma venom acid phosphatase Acph-1-like1 (comp1442_c0_seq1); Lhet-VAPA1.2, L. heterotoma venom acid phosphatase Acph-1-like2 (comp2636_c0_seq1); Lbou-VAPA1, L. boulardi venom acid phosphatase Acph-1-like (comp9544_c0_seq1); Tpre-VAPA1.2, Trichogramma pretiosum venom acid phosphatase Acph-1-like isoform X1 (XP_014234174.2); Fari-VAPA, Fopius arisanus venom acid phosphatase Acph-1-like (XP_011310108.1); Tsar-VAP, T. sarcophagae venom acid phosphatase (OXU23470.1); Mpha-VAPA, Monomorium pharaonis venom acid phosphatase Acph-1-like (XP_012537166.1); Ccin-VAPA, Cephus cinctus venom acid phosphatase Acph-1 (XP_015589422.1); Sinv-VAP, Solenopsis invicta venom acid phosphatase (XP_025987662.1); Veme-VAP1, Vollenhovia emeryi venom acid phosphatase Acph-1-like isoform X1 (XP_011864393.1); Veme-VAP2, V. emeryi venom acid phosphatase Acph-1-like (XP_011872642.1); Aros-VAP, A. rosae venom acid phosphatase Acph-1-like (XP_012251812.1).