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Time‐dependent metabolism of STS‐135 in genotyped HLMs. While CYP3A4 is not highly polymorphic, CYP3A5 is. Genotyped HLMs possessing (A) high (CYP3A5*1*1) and (B) low activity (CYP3A5*3*3) were used to determine whether CYP3A4 or CYP3A5 played a predominant role in the oxidative metabolism of STS‐135. The activity level of CYP3A5 was not shown to affect the production of M25 or M21
