Table 3.
Levels of inflammatory cytokines and TGF-β1 were measured from serum samples in Apoe−/− mice. WD increases levels of IL6, CXCL1, and TNF. Eln+/− mice have increased levels of IL6 and decreased levels of TGF-β1. P values are from two-way ANOVA for diet, Eln genotype, and the interaction between diet and Eln genotype. Significant p values (< 0.05) are shown in italics. N is the number of animals in each group.
| Inflammatory cytokines (pg/ml) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Diet | Genotype | IL6 | IL10 | CXCL1 | TNF | N | TGF-β1 (ng/ml) | N |
| ND | Eln+/+Apoe−/− | 37±31 | 17±4 | 72±34 | 14±8 | 7 | 76±30 | 6 |
| Eln+/−Apoe−/− | 65±39 | 23±24 | 54±14 | 11±2 | 5 | 47±15 | 5 | |
| WD | Eln+/+Apoe−/− | 67±58 | 25±4 | 283±214 | 25±8 | 6 | 54±11 | 7 |
| Eln+/−Apoe−/− | 158±106 | 20±9 | 210±127 | 28±12 | 4 | 40±16 | 4 | |
| P value | Diet | 0.03 | 0.64 | 0.006 | < 0.001 | 0.115 | ||
| Eln | 0.034 | 0.891 | 0.451 | 0.934 | 0.022 | |||
| interactions | 0.244 | 0.35 | 0.649 | 0.386 | 0.372 | |||