Table 1.
Gene Constraint Metrics for Human Selenoproteins from gnomAD v2.1.
| Gene | LOEUF | Decile | oe lof | pLI | LoF |
|---|---|---|---|---|---|
| Selenoproteins | |||||
| DIO1 | 0.63 | 3 | 0.13 | 0.63 | 1 |
| DIO2 | 0.30 | 1 | 0.00 | 0.96 | 0 |
| DIO3 | 0.65 | 3 | 0.14 | 0.62 | 1 |
| GPX1 | 1.89 | 9 | 1.25 | 0.00 | 6 |
| GPX2 | 1.69 | 8 | 0.90 | 0.00 | 6 |
| GPX3 | 0.80 | 4 | 0.35 | 0.05 | 4 |
| GPX4 | 1.28 | 6 | 0.71 | 0.00 | 8 |
| GPX6 | 1.56 | 8 | 0.91 | 0.00 | 9 |
| MSRB1 | 1.13 | 6 | 0.36 | 0.13 | 2 |
| SELENOF | 1.48 | 7 | 0.66 | 0.01 | 4 |
| SELENOH | 1.85 | 9 | 1.10 | 0.00 | 5 |
| SELENOI | 0.44 | 1 | 0.19 | 0.64 | 4 |
| SELENOK | 1.75 | 8 | 0.97 | 0.00 | 6 |
| SELENOM | 1.87 | 9 | 1.23 | 0.00 | 8 |
| SELENON | 1.07 | 5 | 0.72 | 0.00 | 18 |
| SELENOO | 1.69 | 8 | 1.21 | 0.00 | 24 |
| SELENOP | 1.09 | 5 | 0.68 | 0.00 | 12 |
| SELENOS | 1.62 | 8 | 0.99 | 0.00 | 11 |
| SELENOT | 0.82 | 4 | 0.32 | 0.12 | 3 |
| SELENOV | 1.92 | 9 | 1.45 | 0.00 | 13 |
| SELENOW | 1.54 | 7 | 0.80 | 0.00 | 6 |
| SEPHS2 | 1.00 | 5 | 0.51 | 0.00 | 6 |
| TXNRD1 | 0.68 | 3 | 0.41 | 0.00 | 11 |
| TXNRD2 | 0.99 | 5 | 0.69 | 0.00 | 21 |
| TXNRD3 | 0.95 | 4 | 0.62 | 0.00 | 15 |
| Machinery | |||||
| EEFSEC | 1.18 | 6 | 0.76 | 0.00 | 14 |
| PSTK | 0.95 | 5 | 0.55 | 0.00 | 9 |
| SECISBP2 | 1.03 | 5 | 0.77 | 0.00 | 33 |
| SECISBP2L | 0.37 | 1 | 0.23 | 0.29 | 12 |
| SEPHS1 | 0.30 | 1 | 0.06 | 0.98 | 1 |
| SEPSECS | 0.99 | 5 | 0.65 | 0.00 | 16 |
| TRNAU1AP | 0.83 | 4 | 0.47 | 0.00 | 9 |