Table III.
Overview of familial and clinical data.
| Patient | Globozoospermia type | Candidate gene | Ethnicity | Consanguinity | Fertility in family members | Sperm conc. (sperm/ml) reported by IVF clinic | ICSI result |
|---|---|---|---|---|---|---|---|
| GL-1 | 2 | GGN | Turkish | Yes (unknown degree) | 1 brother with globozoospermia (GL-2), 1 fertile brother with 4 children) | < 2 million | 3xICSI: 25% fertilization, no success |
| GL-2 | 2 | GGN | Turkish | Yes (unknown degree) | 1 brother with globozoospermia (GL-1, 1 fertile brother with 4 children) | 2 million | 2xICSI: no fertilization |
| GL-3 | 1 | DNAH17 | French (Mulhouse) | No | 2 fertile sisters | 10 million | 6xIUI: no success 1xIVF with donor sperm: child is born |
| GL-4 | 2 | C2CD6 | Moroccan | Yes (mother is the niece of the father) | 3 brothers and 2 sisters, all fertile | Not available | No ICSI |
| GL-5 | Unknown | None | Unknown | No | Unknown | Unknown | Unknown |
| GL-6 | 1 | None | French (Dijon) | No | 1 brother with globozoospermia (GL-7), 1 infertile half-sister | 38 million | 1xICSI: healthy girl was born |
| GL-7 | 1 | None | French (Dijon) | No | 1 brother with globozoospermia (GL-6), 1 infertile half-sister | 109 million | 2xICSI: no success |
| GL-8 | 2 | None | French (Lille) | No | 2 brothers with globozoospermia including GL-9 | Unknown, 95% atypical sperm | 1xICSI: 25% fertilization, 1 child was born |
| GL-9 | 2 | None | French (Lille) | No | 2 brothers with globozoospermia including GL-8 | Unknown, 98% atypical sperm | 1xICSI: 25% fertilization, 1 child was born, 1 additional pregnancy |
| GL-10 | 1 | None | Not known | No | Unknown | Unknown | Sperm donation: twins were born |
| GL-11 | 1 | ZPBP | Moroccan | Yes (unknown degree) | 2 infertile brothers | 52 million | 2 children |
| GL-12 | Unknown | CCIN | Lebanese | Yes (unknown degree) | 3 infertile brothers, 1 fertile sister | < 2 million | 1xICSI: pregnancy (2011) |
| GL-13 | Unknown | CCDC62 | Lebanese | Yes (unknown degree) | 1 fertile sister, 1 infertile male cousin | 32 million | Unknown |
| GL-14 | Unknown | DPY19L2 | USA | No | Unknown | 4 million | 1xICSI: 1 pregnancy from frozen embryo transfer, healthy boy was born |
| GL-19 | Unknown | None | The Netherlands (indicated as Caucasian) | No | No affected brothers | 180 million | 6xIUI: no pregnancy 1xIVF: no fertilization 3xICSI: 1 healthy girl was born |
| ARG13 | Acrosomal hypoplasia | C7orf61 | Argentina | Yes (unknown degree) | Unknown | Unknown, 95% atypical sperm | Unknown |