Table 1:

Characteristics of the included studies

PMID	Author	Year	Sample size	Age (mean)	Age (median)	Women %	HTN %	DM %	Smoking %	DLP %	CAD %	Plaque imaging	Imaging delay (days)	High-risk features	ROB
24330333	Bayer-Karpinska [5]	2013	32	NA	74	32	72	22	49	28	22	MRI (HRBB)	< 7	ulceration, intraplaque hemorrhage, thrombus	9
29307510	Buon [6]	2018	44	NA	46.5	43	14	2	59	16	NA	Carotid US	NA	ulceration, echolucency, thrombus	9
27412144	Coutinho [7]	2016	85	NA	70	52	60	28	NA	34	20	CTA	< 10	plaque thickness ≥ 3 mm	10
22498329	Freilinger [8]	2012	32	71.7	NA	31	59	22	63	47	22	MRI (HRBB)	5.8	ulceration, intraplaque hemorrhage, thrombus	10
26077590	Gupta [9]	2015	27	71	NA	48	78	22	4	56	11	MRI (3D-TOF)	2.6	intraplaque hemorrhage	8
29571754	Singh [10]	2018	35	74.3	NA	54	74	29	6	80	49	MRI (HRBB)	NA	intraplaque hemorrhage	9
26897689	Gupta [11]	2016	50	69.5	NA	50	NA	NA	NA	NA	NA	MRI (3D-TOF)	1	intraplaque hemorrhage	9
26433367	Hyafil [12]	2016	18	70	NA	63	72	22	17	28	22	MRI (HRBB)	< 14	fibrous cap rupture, intraplaque hemorrhage, thrombus	9

3D-TOF = 3-dimensional time of flight, CAD = Coronary artery disease, DLP = Dyslipidemia, DM = Diabetes mellitus, HRBB = High-resolution black blood, HTN = Hypertension, MRI = Magnetic Resonance Imaging, NA = Not available, PMID = PubMed accession number, ROB = Risk of bias score (maximum 10, 8–10 = low risk of bias/high-quality, 5–7 = moderate risk of bias/moderate quality, ≤4 = high risk of bias/low quality), US = Ultrasound