TABLE II.
(A) Component analysis of subjects reporting allergic reactions to red meat but not having α-Gal sIgE ≥ 0.35 IU/mL. (B) Component analysis of 2 subjects reporting allergic reactions to red meat with α-Gal sIgE ≥ 0.35 IU/mL, but component signature suggestive of pork-cat syndrome
| Demographic | Timing | Total IgE | α-Gal | Beef | Pork | Milk | Cat | Fel d 2 | Sus s 1 |
|---|---|---|---|---|---|---|---|---|---|
| (A) Component analysis of subjects reporting allergic reactions to red meat but not having α-Gal sIgE ≥ 0.35 IU/mL | |||||||||
| Low titer α-Gal | |||||||||
| 42 M | 6 h | 113 | 0.26 | 0.22 | 0.13 | 0.19 | <0.10 | 0.13 | nd |
| 49 F | 4-8 h | 25 | 0.18 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | nd |
| 58 F | 0:20-0:30 | 62 | 0.16 | nd | nd | Nd | nd | nd | nd |
| 52 F | 0:30 | 13 | 0.16 | <0.10 | <0.35 | <0.10 | <0.10 | <0.10 | nd |
| 30 M | 1:30 | 356 | 0.19 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | nd |
| Suggestive of primary beef allergy | |||||||||
| 68 F | 2 h | 85 | 0.2 | 0.42 | 0.11 | 0.24 | <0.10 | <0.10 | nd |
| 47 F | 4 h | 5 | <0.10 | 1.30 | <0.10 | <0.35 | <0.35 | <0.35 | nd |
| 42 F | 3 h | 1157 | <0.10 | 0.18 | 0.11 | <0.35 | <0.35 | <0.10 | nd |
| Suggestive of pork-cat syndrome | |||||||||
| 51 M | 1 h | 83 | <0.10 | <0.10 | 0.65 | <0.35 | 3.74 | 2.28 | 0.62 |
| 16 M | 6-8 h | 277 | <0.10 | <0.10 | 0.28 | 0.11 | 2.83 | 0.10 | 0.19 |
| 43 F | 0:15-5 h | 42 | <0.35 | <0.35 | 0.37 | <0.35 | 3.87 | 4.18 | nd |
| No component diagnosis | |||||||||
| 32 F | 2 h | 71 | <0.10 | <0.10 | <0.10 | <0.10 | <0.35 | <0.35 | nd |
| 50 F | 6 h | 88 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | nd |
| 45 F | 0:30-1 h | 22 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | nd |
| 20 M | 4 h | 74 | <0.10 | <0.10 | <0.10 | <0.10 | 0.13 | <0.10 | nd |
| 28 M | 6 h | 63 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | <0.10 | nd |
| (B) Component analysis of 2 subjects reporting allergic reactions to red meat with α-Gal sIgE ≥ 0.35 IU/mL but component signature suggestive of pork-cat syndrome | |||||||||
| 47 F | 8-12h | 197 | 0.62 | 0.11 | 3.40 | <0.10 | 17.70 | 26.80 | 0.28 |
| 21 F | 0:05 | 328 | 1.41 | 1.10 | 7.10 | 5.08 | 5.71 | 12.30 | nd |
α-Gal, Galactose-α-1,3-galactose; sIgE, specific IgE.
Key for demographics and symptom onset: shown are age (y), sex (M-male, F-female), and time (min) between mammalian meat ingestion and self-reported symptom onset (in cases with 2 values a range of times were reported, reflecting onset during different allergic reactions). All values expressed in IU/mL. Limit of detection varied as either 0.10 IU/mL or 0.35 IU/mL, as indicated; nd denotes serum was not available for assay; values in bold type indicate labs that are consistent with the relevant syndrome.