Comparison 10. Head‐to‐head comparisons.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinician administered scales: Symptom severity	3	432	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.23, 0.14]
1.1 Nefazodone versus sertraline	2	80	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.63, 0.25]
1.2 Venlafaxine versus sertraline	1	352	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.22, 0.20]
2 Comorbid symptoms: Depression (MADRS)	1	26	Mean Difference (IV, Random, 95% CI)	‐0.84 [‐7.88, 6.20]
3 Comorbid symptoms: Anxiety (Hamilton Anxiety Scale)	1	26	Mean Difference (IV, Random, 95% CI)	‐3.23 [‐10.90, 4.44]