Davidson 1990.

Methods	DESIGN Description: balanced randomization, placebo‐controlled, parallel arms, flexible dose, double‐blind, single centre BLINDING Participants: Unclear Assessors: Unclear Administrators: Unclear ALLOCATION CONCEALMENT Method: Unclear RANDOMISATION Method: Unclear
Participants	SAMPLE Description: 46 DSM‐III PTSD, chronic, combat veterans, presumably all males, inpatients included, 20% (9/46) MDD, most common comorbid diagnosis: GAD (16), baseline severity on IES: amitriptyline (33.1) placebo (36.8) SCREENING Primary diagnosis: SI‐PTSD Comorbidity: None
Interventions	Description: amitriptyline (50‐300 mg/d) vs placebo x 8 weeks, ongoing supportive psychotherapy
Outcomes	Primary outcomes: CGI‐I , SI‐PTSD, CGI‐S Secondary outcomes: HAM‐D, HAM‐A, IES, NI, EPI Data estimation: completer values
Notes	INDUSTRY SUPPORT Industry funded: No Medication provided by industry: No Any of the authors work for industry: No ADDITIONAL INFORMATION Drop‐out rates: 8/25 (32%) on amitriptyline, 5/21 (24%) on placebo. Quality rating score: 24
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear