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. 2006 Jan 25;2006(1):CD002795. doi: 10.1002/14651858.CD002795.pub2

Pfizer588.

Methods DESIGN
 Description: Randomised placebo‐controlled, double‐blind, parallel, flexible dose trial
BLINDING
 Participants: Unclear 
 Assessors: Unclear
 Administrators: Unclear
ALLOCATION CONCEALMENT
 Method: Unclear
RANDOMISATION
 Method: Unclear
Participants SAMPLE 
 Description: 193 DSM‐III‐R PTSD, physical/sexual assault, 74.6% female, average age: 37 years, average duration of illness: 10.5 years, baseline severity on CPS‐2: < 50 (except for one participant)
SCREENING
 Primary diagnosis: Unclear
 Comorbidity: Unclear
Interventions Description: sertraline (mean completer dose: 156 mg/d) versus placebo x mean of 74 days
Outcomes CAPS‐2, CGI‐I, IES, DTS, CGI‐S (no distinction made between primary and secondary outcomes)
Data estimation: Unclear
Notes INDUSTRY SUPPORT
 Industry funded: 
 Medication provided by industry: 
 Any of the authors work for industry:
ADDITIONAL INFORMATION
 Drop‐out rates: 50 (25.9%) dropped out in total
 Quality rating score: Not calculated
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk B ‐ Unclear