Pfizer588.
Methods | DESIGN
Description: Randomised placebo‐controlled, double‐blind, parallel, flexible dose trial BLINDING Participants: Unclear Assessors: Unclear Administrators: Unclear ALLOCATION CONCEALMENT Method: Unclear RANDOMISATION Method: Unclear |
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Participants | SAMPLE
Description: 193 DSM‐III‐R PTSD, physical/sexual assault, 74.6% female, average age: 37 years, average duration of illness: 10.5 years, baseline severity on CPS‐2: < 50 (except for one participant) SCREENING Primary diagnosis: Unclear Comorbidity: Unclear |
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Interventions | Description: sertraline (mean completer dose: 156 mg/d) versus placebo x mean of 74 days | |
Outcomes | CAPS‐2, CGI‐I, IES, DTS, CGI‐S (no distinction made between primary and secondary outcomes) Data estimation: Unclear |
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Notes | INDUSTRY SUPPORT
Industry funded:
Medication provided by industry:
Any of the authors work for industry: ADDITIONAL INFORMATION Drop‐out rates: 50 (25.9%) dropped out in total Quality rating score: Not calculated |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Unclear risk | B ‐ Unclear |