van der Kolk 2004.

Methods	DESIGN Description: random‐assignment, placebo‐controlled, parallel arm, flexible‐dose, double‐blind, multi‐centre, 6 month follow‐up BLINDING Participants: Unclear Assessors: Yes Administrators: Unclear ALLOCATION CONCEALMENT Method: No information RANDOMISATION Method: Unclear
Participants	SAMPLE Description: 59 DSM‐IV PTSD, mean age: 34.9 years (18‐65), 86% (51/59) female, average duration of diagnosis: 13.3 years, baseline severity on CAPS: fluoxetine (73.7) and placebo (70.3) SCREENING Primary diagnosis: Trauma incident >= 1 year ago, GAF < 40 Comorbidity: Not mentioned
Interventions	Description: fluoxetine 10 mg/d ‐ 60 mg/d versus Eye Movement Desensitization and Reprocessing (EMDR) versus placebo x 5 weeks
Outcomes	Primary outcomes: CAPS Secondary outcomes: BDI Data estimation: LOCF
Notes	INDUSTRY SUPPORT Industry funded: No Medication provided by industry: Unclear Any of the authors work for industry: No ADDITIONAL INFORMATION Drop‐out rates: 13% (4/30) on fluoxetine and 10% (3/29) on placebo Quality rating score: 28
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear