Table 3. Application of the Bland–Altman limits of agreement to a plausible range of AD meta-analysis HRs.

Observed AD meta-analysis HR	Potential IPD meta-analysis HR (after dividing by the limits of agreement: 0.90 and 1.05)	Observed control group survival band	Potential IPD meta-analysis absolute survival effects at a representative control group value
0.70	0.67 to 0.78	<10%	5% to 8%
		10%–19%	8% to 13%
		20%–49%	9% to 14%
		50%–69%	7% to 11%
		≥70%	5% to 7%
0.75	0.71 to 0.83	<10%	3% to 7%
		10%–19%	6% to 10%
		20%–49%	7% to 11%
		50%–69%	5% to 9%
		≥70%	3% to 6%
0.80	0.76 to 0.89	<10%	2% to 5%
		10%–19%	4% to 8%
		20%–49%	4% to 10%
		50%–69%	4% to 8%
		≥70%	2% to 5%
0.85	0.81 to 0.94	<10%	1% to 4%
		10%–19%	2% to 6%
		20%–49%	2% to 7%
		50%–69%	2% to 6%
		≥70%	1% to 4%
0.90	0.86 to 1.00	<10%	0% to 2%
		10%–19%	0% to 4%
		20%–49%	0% to 5%
		50%–69%	0% to 4%
		≥70%	0% to 3%
0.95	0.90 to 1.05	<10%	−1% to 1%
		10%–19%	−2% to 3%
		20%–49%	−2% to 3%
		50%–69	−2% to 3%
		≥70%	−1% to 2%

AD, aggregate data; HR, hazard ratio; IPD, individual participant data.