Figure 3.

Workflow to generate a customized list of on-label, off-label, and/or clinical trial therapy options. Therapy options listed in reports finalized by the VMTB take into account both the actionability and accessibility of specific interventions available to a patient in clinical trials and as on or off-label treatments. We implemented a customized trial matching algorithm to identify relevant trials for an individual patient by aligning patient data to structured eligibility criteria. These data can also be used to provide VMTB users with a preranked list of trials by approximating the three therapy option scoring vectors (molecular rationale, disease relevance, and patient history).