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. 2020 Jan 6;130(2):813–826. doi: 10.1172/JCI129308

Figure 5. Neural crest marker expression rescued in emc1 morphants by modulating β-catenin.

Figure 5

Expression of sox10 in control MO-injected embryos raised in media containing DMSO showed stereotyped expression of this marker at stage 20; loss of sox10 expression in stage 20 embryos was observed after injection with emc1 MO. sox10 expression was partially rescued by injection of NLS-fused β-catenin mRNA or the small molecular GSK3β inhibitor CHIR 99021. Three replicates of 15 embryos were analyzed for each condition. Scale bar: 500 μm.