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. 2020 Jan 13;130(2):877–889. doi: 10.1172/JCI130363

Figure 6. Summary of the molecular pathways within the neuron in the presence of TAT-GRpep.

Figure 6

(A) TAT-GRpep is able to pass through the blood brain barrier and enter into the neuron due to the TAT sequence. (B) Once TAT-GRpep enters the cell, it competes with GR in binding to FKBP51. (C) More GR is phosphorylated and (D) consequently, more GR can bind to FKBP52. (E) Both events are responsible for translocating GR into the nucleus, where it binds to specific DNA sequences and promotes transcription.