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. 2019 Dec 17;130(2):e127341. doi: 10.1172/JCI127341

Figure 6. Placental and embryonic hepcidin does not regulate placental iron homeostasis under iron-replete or iron-deficient conditions.

Figure 6

Hamp+/– female mice were mated with Hamp+/– male mice. Females were placed on an iron-replete or iron-deficient diet 1 week prior to mating. Placentas and embryos were analyzed on E18.5. (A) Fetal liver iron and (B) fetal serum iron concentrations. (C) Placental iron concentration, (D) Hamp expression, (E) Tfrc expression, and (F) FPN protein levels. Statistical differences between groups were determined by 2-way ANOVA (non-normally distributed values are indicated by an asterisk). The P value shown is for variation by diet. There were no statistical differences between genotypes for any of the measured parameters. The numbers of animals are indicated in the x axes of the box and whisker plots. E, embryos; M, mothers; Het, heterozygous.