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. 2020 Jan 21;130(2):1024–1035. doi: 10.1172/JCI131493

Figure 7. Pharmacological inhibition of EphA4 increases pial collateral size 4 days after pMCAO.

Figure 7

(A) MCA-ACA collaterals (yellow arrows) show that KYL significantly increased the diameter of ipsilateral MCA-ACA inter-collaterals compared with those treated with vehicle (saline) (*). Both vehicle and KYL ipsilateral collaterals are significantly larger compared with contralateral (#). (B) MCA-PCA ipsilateral inter-collaterals of animals treated with KYL are also significantly larger compared with those of vehicle control. (C) Quantified graph showing that the average inter-collateral diameter after stroke is increase in KYL-treated mice. (D) Representative images of WT vessel painted ipsilateral hemisphere with vehicle treatment compared with (E) KYL treatment. (F) Breakdown of collateral sizes after pMCAO shows a significant increase in the percentage of collaterals whose diameters are greater than 51 μm, and a precipitous drop in the percentage of collaterals whose diameters are between 21–30 μm in KYL mice; n = 8 mice per group. One-way and 2-way ANOVA with Bonferroni’s post hoc test. *,#P < 0.05; **P < 0.01; ***P < 0.001; ****,####P < 0.0001. Scale bars: 500 μm.