(
A) A pathway for
cis-carotene and xanthophyll synthesis. Tri-
cis-ζ-carotene and tetra-
cis-lycopene are isomerised by ZISO and CRTISO to form di-
cis-ζ-carotene and lycopene, respectively.
ziso and
ccr2 mutants accumulate
cis-carotenes (
Park et al., 2002;
Chen et al., 2010). In the light, photoisomerisation facilitates
cis-carotene isomerisation. Norflurazon (NF) inhibits PDS activity. CAROTENOID CLEAVAGE DIOXYGENASE (CCD) activity may cleave
cis-carotenes to generate an apocarotenoid signal (ACS) (
Kachanovsky et al., 2012;
Fantini et al., 2013;
Avendaño-Vázquez et al., 2014;
Álvarez et al., 2016). Chemical treatment of seedlings with D15 can inhibit CCD activity and enhance carotenoid accumulation (
Van Norman et al., 2014). Mutants that block the production of lutein (
lut2; lutein-deficient 2), strigolactone (
max4-3; more axillary branching 4) and abscisic acid (
aba1-3; aba deficient 1) were utilised to interrogate the cause of the
ccr2 leaf virescence phenotype. (
B) Control of prolamellar body (PLB) formation and protein levels during skotomorphogenesis. DET1 acts as a repressor of photomorphogenesis in etiolated tissues to maintain high PIF3 and low HY5 protein levels, which reduce
PHOTOSYNTHESIS ASSOCIATED NUCLEAR GENE (
PhANG) expression.
det1 mutants do not accumulate PORA and do not form a PLB within the etioplast. Upon de-etiolation, the protein levels DET1 and PIF3 decline and HY5 increases, which induces
PhANG expression. Grey insert boxes digitally represent published western protein blots for PORA (
Lebedev et al., 1995), PIF3 (
Dong et al., 2014) and HY5 (
Osterlund et al., 2000) in WT and
det1 mutant genotypes. Solid black and grey fills represents high and low protein expression, respectively. Green arrows and red lines represent positive and negative regulation, respectively. Abbreviations: GGPP, geranylgeranyl pyrophosphate; PSY, PHYTOENE SYNTHASE; PDS, PHYTOENE DESATURASE, ZDS, ζ-CAROTENE DESATURASE; ZISO, ζ-CAROTENE ISOMERASE; CRTISO, CAROTENOID ISOMERASE.