Table 4.
Comparison of phenotype and quantitative traits according to the BA profile based on BOTH total fecal excretion of BA per 48 h or hepatic BA synthesis (fasting serum C4)
| Data mean±s.e.m. | Fecal BA and serum C4 > 90% | Fecal BA and serum C4 < 90% |
|---|---|---|
| N | 5 | 27 |
| Age, years | 47.8±2.3 | 39.6±2.3 |
| BMI, kg/m2 | 31.8±3.6 | 26.3±0.9 |
| Anxiety score (HAD) | 3.8±1.1 | 4.5±0.8 |
| Depression score (HAD) | 1.6±0.7 | 1.4±0.4 |
| No. of BM/day | 1.6±0.2 | 2.1±0.2 |
| BM form | 4.1±0.5 | 4.7±0.1 |
| Fecal fat (g/day) | 8.0±3.3 | 7.1±1.1 |
| Serum C4 (ng/ml) | 63.2±3.7 | 19.2±1.7 |
| Serum FGF19 (pg/ml) | 140.3±50.4 | 128.0±14.9 |
| Total fecal BA (mM) | 5,556±1,682 | 820±120 |
| Mean % fecal LCA/CDCA/DCA/CA | 31/5/52/9 | 36/5/51/5 |
| Colonic transit GC24 | 2.9±0.7 | 2.7±0.2 |
| Colonic transit GC48 | 4.0±0.6 | 4.0±0.2 |
| Postprandial/fast. colonic tone, % | 17.8±9.6 | 28.9±4.1 |
| Colon sensation threshold, first | 20.8±7.4 | 10.8±2.1 |
| Colon sensation threshold, gas | 27.2±8.8 | 20.2±3.1 |
| Colon sensation threshold, pain | 37.6±9.5 | 44.4±3.5 |
| Urine mannitol, 0–2 h | 373±59 | 309±44 |
| Urine mannitol, 8–24 h | 58.0±15.7 | 45.8±8.7 |
BA, bile acid; BM, bowel movements; BMI, body mass index; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; Fast., fasting; FGF19, fibroblast growth factor 19; GC, geometric center; HAD, Hospital Anxiety and Depression; LCA, lithocholic acid; MI, motility index.