. Author manuscript; available in PMC: 2020 Jan 31.

Published in final edited form as: Am J Gastroenterol. 2014 Jul 29;109(10):1621–1630. doi: 10.1038/ajg.2014.215

Table 5.

Associations of IBS-D subgroups (increased fecal excretion or synthesis of bile acids and serum C4) with specific SNP genotypes

Genotype	Elevated total fecal BA subgroup	Elevated C4 subgroup
KLB rs17618244	0.79	1.00
KLB rs1015450	0.16	0.06
FGFR4 rs351855	0.85	0.14
FGFR4 rs1966265	0.43	0.09
FGFR4 rs434434	0.55	0.46

BA, bile acid; FGFR4, fibroblast growth factor receptor 4; IBS-D, irritable bowel syndrome-diarrhea; KLB, klotho B; SNP, single-nucleotide polymorphism.

P values based on Fisher’s exact test.