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Domain arrangement for dual-cytokine fusion proteins. These homotrimeric fusion proteins feature antibodies in scFv fused to members of the TNF superfamily and to other immunomodulatory payloads. (A) Dual-cytokine fusion protein based on IL2 and murine (m) TNF. (B) Fusion protein featuring 4-1BBL, IL15, and the alpha-subunit of the IL15 receptor (RD). The VH and VL domains of antibodies in scFv format are indicated.
