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. Author manuscript; available in PMC: 2021 Jan 3.
Published in final edited form as: Org Lett. 2019 Oct 17;22(1):1–5. doi: 10.1021/acs.orglett.9b03434

Figure 4.

Figure 4.

Scope of the amide substrate. General conditions unless otherwise stated: amide substrate (1.0 equiv, 0.4 mmol), K3PO4 (4.0 equiv), boronic ester 5 (5.0 equiv), Ni(cod)2 (5 mol%), Benz-ICy·HCl (10 mol%), and 1,4-dioxane (1.0 M) heated at 120 °C for 24 h in a sealed vial under an atmosphere of N2. Unless otherwise noted, yields reflect the average of two isolation experiments. Yields in parentheses were obtained by carrying out the reaction in a glovebox utilizing literature conditions without encapsulating Ni(cod)2 and Benz-ICy·HCl in paraffin. a Yield was determined by 1H NMR analysis using 1,3,5-trimethoxybenzene as an external standard.