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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Arch Pharm Res. 2019 Aug 1;43(3):361–369. doi: 10.1007/s12272-019-01177-2

Figure 2: The role of NRF2 in kidney disease.

Figure 2:

Accumulation of Reactive Oxygen Species (ROS) is linked to a variety of kidney diseases. NRF2 negates the effects of ROS, and therefore can prevent or delay the onset of these diseases. However, high levels of NRF2 have also been reported to promote hydronephrosis and renal cancers.