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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Arthritis Rheumatol. 2019 Dec 26;72(2):251–261. doi: 10.1002/art.41091

Figure 2. Two endotypes identified among RA cases based on trajectories of autoantibody isotypes.

Figure 2.

In the ‘early’ endotype (116 RA cases, green lines), RF and ACPA IgG and A autoantibodies began to increase from controls (blue lines) early in the pre-RA period (Figure 2A-D). RF-IgM and ACPA-IgM trajectories are not pictured but are within the range of IgG and A autoantibodies for each endotype. In contrast, in the ‘late’ endotype (98 cases, red lines) RF and ACPA IgG and A autoantibodies showed an increase from controls (blue lines) just proximal to the diagnosis of RA (Figure 2A-D, red lines).