Table 3.
Associations between transitional radiographic changes and baseline characteristics and the changes in lung function, skin score and dyspnea
| Net Improvement | ||||||
|---|---|---|---|---|---|---|
| Whole Lung | Most Severe Lobe | |||||
| PGG→NL -PNL→GG | PLF→GG -PGG→LF | PLF→NL - PNL→LF | PGG→NL-PNL→GG | PLF→GG -PGG→LF | PLF→NL - PNL→LF | |
| Baseline Characteristics : Spearman rank correlation: rho (p-value) | ||||||
| Male, % | −0.26 (p=0.011*) |
−0.24 (p=0.02*) |
−0.15 (p=0.14) |
−0.24 (p=0.018*) |
−0.23 (p=0.024*) |
−0.16 (p=0.12) |
| Age, yr | 0.12 (p=0.23) |
−0.03 (p=0.74) |
−0.09 (p=0.37) |
0.15 (p=0.15) |
−0.014 (p=0.89) |
−0.06 (p=0.56) |
| Disease Duration | −0.09 (p=0.37) |
−0.11 (p=0.30) |
−0.17 (p=0.10) |
−0.17 (p=0.10) |
−0.13 (p=0.19) |
−0.10 (p=0.34) |
| % pred FVC | 0.04 (p=0.69) |
0.23 (p=0.021*) |
0.39 (p=0.0001*) |
0.08 (p=0.45) |
0.31 (p=0.0024*) |
0.38 (p=0.0001*) |
| FEV1/FVC | −0.24 (p=0.017*) |
−0.15 (p=0.14) |
−0.20 (p=0.052) |
−0.16 (p=0.12) |
−0.18 (p=0.077) |
−0.17 (p=0.094) |
| % pred DLCO | 0.20 (p=0.0501) |
0.23 (p=0.021*) |
0.33 (p=0.001*) |
0.24 (p=0.02*) |
0.25 (p=0.014*) |
0.30 (p=0.0025*) |
| mRSS | −0.07 (p=0.48) |
0.11 (p=0.21) |
0.15 (p=0.14) |
−0.03 (p=0.79) |
0.10 (p=0.35) |
0.10 (p=0.34) |
| BDI++ | 0.26 (p=0.011*) |
0.14 (p=0.20) |
0.22 (p=0.03*) |
0.26 (p=0.012*) |
0.20 (p=0.049*) |
0.25 (p=0.014*) |
| QLF whole lung,% | −0.29 (p=0.0046*) |
−0.37 (p=0.0002*) |
−0.67 (p<0.0001*) |
−0.32 (p=0.0013*) |
−0.49 (p<0.0001*) |
−0.71 (p<0.0001*) |
| QILD whole lung, % | −0.31 (p=0.0018*) |
−0.18 (p=0.07) |
−0.46 (p<0.0001*) |
−0.33 (p=0.0011*) |
−0.30 (p=0.0025*) |
−0.4881 (p<0.0001*) |
| QLF Most Severe Lobe, % | −0.30 (p=0.003*) |
−0.40 (p=0.0001*) |
−0.70 (p<0.0001*) |
−0.36 (p=0.0003*) |
−0.53 (p<0.0001*) |
−0.77 (p<0.0001*) |
| QILD Most Severe Lobe,% | −0.35 (p=0.0004*) |
−0.28 (p=0.0049*) |
−0.60 (p<0.0001*) |
−0.43 (p<0.0001*) |
−0.43 (p<0.0001*) |
−0.69 (p<0.0001*) |
| 24 Month Changes: Net Improvement, Spearman rank correlation: rho (p-value) | ||||||
| PGG→NL -PNL→GG | PLF→GG -PGG→LF | PLF→NL - PNL→LF | PGG→NL-PNL→GG | PLF→GG -PGG→LF | PLF→NL - PNL→LF | |
| Changes in % predicted FVC | 0.33 (p=0.0009*) |
0.45 (p<0.0001*) |
0.21 (p=0.036*) |
0.3368 (p=0.0007*) |
0.4078 (p<0.0001*) |
0.1787 (p=0.0798) |
| Changes in % predicted DLCO | 0.24 (p=0.022*) |
0.23 (p=0.028*) |
0.08 (p=0.43) |
0.20 (p=0.050 ) |
0.21 (p=0.042*) |
0.14 (p=0.17) |
| %Changes in TLC | 0.28 (p=0.0059*) |
0.31 (p=0.002*) |
0.21 (p=0.042*) |
0.32 (p=0.0017*) |
0.29 (p=0.004*) |
0.14 (p=0.18) |
| % Changes in FEV1/FVC | 0.02 (p=0.88) |
0.03 (p=0.74) |
−0.03 (p=0.81) |
0.00 (p=1.00) |
0.11 (p=0.30) |
0.05 (p=0.66) |
| Change in skin score | −0.107 (p=0.30) | −0.27 (p=0.0066*) | −0.32 (p=0.0016*) |
−0.13 (p=0.19) |
−0.25 (p=0.014*) |
−0.29 (p=0.0043*) |
| TDI | 0.22 (p=0.059) |
0.16 (p=0.19) |
0.14 (p=0.25) |
0.16 (p=0.18) |
0.09 (p=0.46) |
−0.0028 (p=0.98) |
% pred = % predicted; FVC = Forced Vital Capacity; FEV1= Forced Expiratory Volume in one second; DLCO = Diffusing capacity of the Lung for carbon monoxide; TLC = Total Lung Capacity; RV = Residual Volume; mRSS = modified Rodnan Skin Score; QLF = Quantitative Lung Fibrosis; QILD = Quantitative Interstitial Lung Disease= QLF+QGG+QHC= 100%- QNL; BDI = Baseline Dyspnea Index which ranges from 0 (most severe) to 12 (unimpaired). N=97 for changes in skin score: a negative change represents improvement and a positive change represents worsening; N=72 for transition dyspnea index (TDI): a negative change represents worsening and a positive change represents improvement.
N=42 for CYC and N=47 for MMF
N=93 for BDI