Figure 3.

Aβ Deposits in the Brain by Immunohistochemistry

Mouse brains were removed and subjected to immunohistochemistry, as described in Materials and Methods. (A and B) The brain slices of normal C57BL mice initially (A) and at 1 month later (B). (C and D) The brain slices of the untreated AD control group initially (C) and at 1 month later (D). Aβ deposits are marked by yellow arrows. (E) The brain slices of the AD experimental group at 1 month prior to hNEP delivery. More Aβ deposits were found (yellow arrows). (F) The brain slices of the AD experimental group at 1 month after hNEP delivery by US. Aβ deposits were significantly decreased in the cortex and hippocampus (scale bars, 1,000 μm).