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. 2020 Jan 31;10:1558. doi: 10.1038/s41598-020-57588-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-548x and miR-4698 inhibited AKT1 protein expression in human glioblastoma cell lines. Protein expression was investigated 72 h post-transduction by western-blot analysis. Overexpression of miR-548x or miR-4698 could decrease the protein expression of AKT1 in A-172 (A) and U251 (B) cell lines compared with the control cells. Also, western blot analysis indicated a reduction in protein level of AKT1 in A-172and U251 (C,D) cell lines compared with the respective control. Protein normalization was achieved with β-actin for AKT1. Data are presented as mean ± SD of results from 3 independent investigations, (^∗P < 0.05) as compared with the control.