Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 31;10:1589. doi: 10.1038/s41598-020-58559-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

3D model of MuV-HN in complex with trisaccharide 1 and CORCEMA analysis. (a) Close up view of ligand 1 binding mode at the MuV-HN active site, drawn by using Pymol 2.3 Software (https://pymol.org/2/). The main amino acid residues involved in the binding are represented in stick. Galactose and N-acetyl Glucosamine residues are depicted in yellow and blue, respectively. (b) Two-dimensional plot illustrating the interactions of the sialylated trisaccharide 1 with the residues in the binding pocket of MuV-HN derived by a tool included in Maestro Version 10.5.014 (https://www.schrodinger.com/maestro). Dotted arrows represent hydrogen bonds with functional groups from side chains and solid arrows such with functional groups of the backbone. The residues shown, close to the ligand, are involved into hydrophobic and polar interactions. (c) Comparison between experimental (dashed line) and theoretical (solid line) STD data for the selected 3D complex of the interaction between trisaccharide 1 and MuV-HN head domain.