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. 2020 Jan 31;10:1563. doi: 10.1038/s41598-020-58502-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier survival curves of the mice with HPV-negative (FaDu) or HPV-positive (2A3) tumors after concurrent treatment with i.v. injection of cisplatin (CDDP) and single (IR) (a) or fractionated irradiation (FIR) (b). *p < 0.05 between treatments for FIR vs FIR + CDDP in FaDu tumors; **p < 0.05 between treatments for IR 10 Gy + CDDP vs FIR + CDDP in FaDu tumors; ***p < 0.05 between treatments for FIR vs FIR + CDDP in 2A3 tumors; ****p < 0.05 between treatments for IR 10 Gy + CDDP vs FIR + CDDP in 2A3 tumors; ^#p < 0.05 between treatments for FIR + CDDP in FaDu vs FIR + CDDP in 2A3 tumors; n = 8–12 mice. CTRL, the control group.