Fig. 3.

Neuroprotection by semaglutide is at least as strong as by liraglutide and is mediated by GLP-1Rs. Rats were subjected to 90-min MCAO, followed by 72-h reperfusion. Liraglutide (Lir.) or semaglutide (Sem.) was administered s.c. 5 min before the onset of reperfusion. Hemispheric lesion volumes corrected for oedema (%HLVe) (a) and neuroscores (b) were evaluated at the end of reperfusion period. Individual data and median with interquartile range are shown for each group. The numbers of the animals who did not survive 72-h reperfusion or had to be euthanised due to having reached the humane endpoints are presented in the boxes. *P < 0.05; **P < 0.01; ***P < 0.001