Fig. 6. Similarity analysis of in vitro PSC-derived and in vivo lung progenitors.

a Schematic depicting the four types of in vitro PSC-derived progenitors using a lung specification cocktail (in vitro-derived lineages) and derivation of similarity scores to in vivo populations (reference lineages) via two methods, namely linear projection analysis (LAP) and gene set analysis (GSA) (b–d). Projections strength scores from LAP analysis for the four populations shown in a, including projections to lung endodermal populations (b), non-lung endoderm (c), and mesenchymal-like populations (d). Scores shown in Fig. 5a are re-plotted here for comparison purposes. e Projection scores from gene set analysis using the reference cell populations from b–d and Supplementary Fig. 7A with bulk RNA-Seq data.