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. 2020 Jan 31;10:1597. doi: 10.1038/s41598-020-58482-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of HIF-PHD inhibitors on HIF-1α levels in primary rat neurons. Immunoblot analysis of HIF-1α levels in primary cortical neurons treated with 24 hours with 1% DMSO, FG4592 (10, 30 50, 100 µM) and DMOG (100, 250 µM) in normoxia. (A) Representative HIF-1α immunoblots were shown with those for β-actin; (B) Graph (n = 3) showed the normalised HIF-1α level measured at 24 hours after exposure to FG4592 or DMOG in normoxia. FG4592 (30 µM onwards) and DMOG (100, 250 µM) significantly increased HIF-1α levels in primary rat neurons. Error bars represent ± S.D. *Indicates P < 0.05 against control (1% DMSO treatment) (Two-way ANOVA, Tukey’s post-hoc analysis).