Table 4.

Multiple regression analysis of predictors of the time until the BIS exceeded 60.

Variable	Estimated coefficient	Standard error	P-value
Intercept	9.018	7.340	0.234
Group (poly-VPA)	−1.951	0.597	0.004
Age	0.074	0.056	0.198
Sex (female)	−0.044	0.529	0.934
BMI	0.177	0.113	0.134
Non-ID	0.311	0.546	0.575
Non-liver dysfunction	−0.301	0.556	0.594
Alb	−1.553	1.409	0.284
Propofol level	−1.297	1.623	0.434
Free propofol level	34.337	52.394	0.520

R² = 0.620.

BMI: body mass index, ID: intellectual disability, Alb: albumin.

See text for the definition of suspected liver dysfunction.