Table 1.
Changes in cytotoxicity and RS rhythms† for different time points of drug addition.
| Time of drug addition | Parameter | Untreated control | curcumin | menadione | |||
|---|---|---|---|---|---|---|---|
| SiHa | HCT116 | SiHa | HCT116 | SiHa | HCT116 | ||
| 0 h drug addition | superoxide rhythm period (h) | 15.38 | 22.59 | 9.62 | 8.17 | 10.99 | 12.00 |
| Hydroxyl rhythm period (h) | 25.00 | 20.21 | 11.11 | 8.90 | 21.74 | 15.36 | |
| 4 h drug addition | superoxide rhythm period (h) | 15.38 | 22.59 | 9.17 | 9.17 | 9.62 | 12.82 |
| Hydroxyl rhythm period (h) | 25.00 | 20.21 | 8.33 | 9.60 | 20.41 | 20.25 | |
| 8 h drug addition | superoxide rhythm period (h) | 15.38 | 22.59 | 12.05 | —* | 12.35 | 12.35 |
| Hydroxyl rhythm period (h) | 25.00 | 20.21 | 23.81 | 10.11 | 25.00 | 20.25 | |
†Data averaged for n = 3. The rhythm periods are given for p < 0.01 by LSP analysis using the software PAST. The power spectra with individual p values are given in the Supplementary Information.
*No significant rhythm was found.