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. 2020 Jan 31;10:1545. doi: 10.1038/s41598-020-58114-3

Table 1.

Demographics of the patient population divided by pregnancies that resulted in a first trimester loss and those that progressed beyond the first trimester (continuing pregnancy).

Demographics First Trimester Pregnancy Loss N = 52 Continuing Pregnancy N = 243 p-value
Age (years) [Median (Q1, Q3)] 34.0 (31.0, 36.3) 32.0 (29.0, 35.0) 0.067a
Gravidity (N) [Median (Q1, Q3)] 2.0 (1.0, 3.0) 2.0 (1.0, 3.0) 0.440a
Parity (N) [Median (Q1, Q3)] 0 (0, 1.0) 0 (0, 1.0) 0.324a
BMI (kg/m2) [Median (Q1, Q3)] 26.1 (22.0, 30.5) 25.0 (22.0, 31.0) 0.785a
Mode of conception* (percentage)
Spontaneous 22 (42.3%) 66 (31.6%) 0.189b
Ovulation induction (OI) 8 (15.4%) 27 (12.9%) 0.399b
OI + Intrauterine Insemination 6 (11.5%) 27 (12.9%) 0.060b
In vitro Fertilization 16 (30.7%) 89 (42.6%) 0.081b
Clinical Condition** (percentage)
Smoking 2 (3.8%) 14 (6.7%) 0.440b
PCOS 35 (67.3%) 154 (73.7%) 0.357b
Glucose Intolerance 6 (11.5%) 29 (13.9%) 0.658b
Hypothyroidism 8 (15.4%) 34 (16.3%) 0.877b
Hypertension 1 (1.9%) 4 (1.9%) 0.997b
Autoimmune disease 2 (3.8%) 16 (7.7%) 0.429b
Uterine Subseptation 12 (23.1%) 30 (14.4%) 0.126b
Uterine Fibroids 6 (11.5%) 33 (15.8%) 0.442b
Endometriosis 3 (5.8%) 17 (8.1%) 0.566b

aMann-Whitney U test; bPearson Chi-Square.

*In twin, or triplet, pregnancies whit one, or two, miscarried embryos and one viable embryo, the same patient was counted in both groups.

**Pregnancies in both groups occurred after corrections of the underlying conditions. PCOS was diagnosed using the Rotterdam criteria17; Glucose intolerance was defined as hemoglobin A1c ≥ 5.7%; Hypothyroidism was defined by a TSH ≥ 2.5 mIU/l; Hypertension was defined as blood pressure ≥140/90; Autoimmune disease encompassed systemic Lupus Erythematosus, Lupus Anticoagulant, Anticardiolipin antibodies, AntiPhosphatidil antibodies; Uterine subseptations were treated when measuring ≥5.9 mm.