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. 2020 Jan 31;10:1638. doi: 10.1038/s41598-019-57364-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumour growth inhibition was greater for tumours that reoxygenated more during radiotherapy. Mean scaled tumour volumes—volumes divided by volumes at the start of radiation—are shown as a function of time after the end of radiotherapy for irradiated tumours segregated into two groups based on reoxygenation: ΔHF_1.4 < −0.09 (the median value for ΔHF_1.4) and ΔHF_1.4 > −0.09. Error bars indicate the standard deviation of scaled tumour volumes in each group. The number of mice n in each group are shown above and below error bars; where not shown, n = 6. The analogous plots using ΔHF_3σ are essentially the same. Mann-Whitney U test p-values were 0.08, 0.12, 0.02, and 0.02, 0.053 at 50, 100, 127, 183, and 219 days after completion of SBRT, respectively. The test was not significant (p > 0.05) at the last volume measurement (219 days post-SBRT) because only 4 mice lived to this time.