Table 1.

List of identified metabolites as detected respectively by HR-MAS NMR analysis of whole cells, or from aqueous extracts by conventional solution NMR acquisition, for PSC and differentiated (Diff) cells samples.

	Metabolite	NMR Platform	Cell Types
1	4-aminobutyrate	HR-MAS, Aq. extracts	Diff, PSC
2	Acetate	HR-MAS, Aq. extracts	Diff, PSC
3	Acetylcholine	HR-MAS, Aq. extracts	Diff, PSC
4	ADP	HR-MAS, Aq. extracts	Diffa, PSC
5	Alanine	HR-MAS, Aq. extracts	Diff, PSC
6	AMP	HR-MAS, Aq. extracts	Diff, PSC
7	Ascorbate	HR-MAS, Aq. extracts	Diff, PSC
8	Choline	HR-MAS, Aq. extracts	Diff, PSC
9	Creatine	HR-MAS, Aq. extracts	Diff, PSC
10	Formate	HR-MAS, Aq. extracts	Diff, PSC
11	Glutamate	HR-MAS, Aq. extracts	Diff, PSC
12	Glutathione	HR-MAS, Aq. extracts	Diff, PSC
13	Glycerophosphocholine (GPC)	HR-MAS, Aq. extracts	Diff, PSC
14	Glycine	HR-MAS, Aq. extracts	Diff, PSC
15	Inosine	HR-MAS, Aq. extracts	Diff, PSCb
16	Isocitrate	HR-MAS, Aq. extracts	Diff, PSC
17	Isoleucine	HR-MAS, Aq. extracts	Diff, PSC
18	L-Lactate	HR-MAS, Aq. extracts	Diff, PSC
19	Leucine	HR-MAS, Aq. extracts	Diff, PSC
20	Myo-inositol	HR-MAS, Aq. extracts	Diff, PSC
21	NAD+	HR-MAS, Aq. extracts	Diff, PSCa
22	Phenylalanine	HR-MAS, Aq. extracts	Diff, PSC
23	Phosphocholine (PC)	HR-MAS, Aq. extracts	Diff, PSC
24	Proline	HR-MAS, Aq. extracts	Diff, PSC
25	Pyruvate	HR-MAS, Aq. extracts	Diff, PSC
26	Serine	HR-MAS, Aq. extracts	Diff, PSC
27	Threonine	HR-MAS, Aq. extracts	Diff, PSC
28	Tyrosine	HR-MAS, Aq. extracts	Diff, PSC
29	UDP-galactose	HR-MAS, Aq. extracts	Diff, PSC
30	UDP-glucose	HR-MAS, Aq. extracts	Diff, PSC
31	UDP-glucuronate	HR-MAS, Aq. extracts	Diff, PSC
32	UDP-N-acetylglucosamine	HR-MAS, Aq. extracts	Diff, PSC
33	Valine	HR-MAS, Aq. extracts	Diff, PSC
34	Glycerol	HR-MAS, Aq. extracts	Diff
35	Taurine	HR-MAS, Aq. extracts	PSC
36	Adenine	HR-MAS	Diff, PSC
37	Asparagine	HR-MAS	Diff, PSC
38	Butyrate	HR-MAS	Diff, PSC
39	Cytidine	HR-MAS	Diff, PSC
40	Glutamine	HR-MAS	Diff, PSC
41	Guanosine	HR-MAS	Diff, PSC
42	Homocysteine	HR-MAS	Diff, PSC
43	Homocystine	HR-MAS	Diff, PSC
44	Methionine	HR-MAS	Diff, PSC
45	Nicotinamide	HR-MAS	Diff, PSC
46	Uracil	HR-MAS	Diff, PSC
47	Uridine	HR-MAS	Diff, PSC
48	Citrate	HR-MAS	Diff
49	N-acetylglutamine	HR-MAS	Diff
50	Tryptophan	HR-MAS	Diff
51	Arginine	Aq. Extracts	Diff, PSC
52	Aspartate	Aq. Extracts	Diff, PSC
53	GTP	Aq. Extracts	Diff, PSC
54	N-acetylcysteine	Aq. Extracts	Diff, PSC
55	Succinate	Aq. extracts	Diff, PSC
56	UMP	Aq. extracts	Diff

^aOnly in aqueous extracts; ^bby HR-MAS only.