Fig. 1.

(A–D) Representative simultaneous recordings of surface ECG in ibrutinib-treated mice and control mice following programmed intracardiac stimulation (n = 6 mice per group; Fig. 1B, Chi-square test; Fig. 1A, C, D, Student's t-test). AF, atrial fibrillation. (E–H) Representative B-mode and M-mode echocardiography recordings and (I–L) quantification of left atrial (LA) diameter, LA area, left ventricular internal dimension systole (LVIDs) and E/A peak in control and ibrutinib-treated mice (n = 4 mice per group; Student's t-test). Values are presented as mean ± SD. *P < 0.05, **P < 0.01 vs Control group.