Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 31;11:655. doi: 10.1038/s41467-020-14284-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Correspondence between primary viability outcomes in mice and human cell line screens. The sankey diagram shows how human orthologues of mouse genes with IMPC primary viability assessment (lethal, subviable and viable) regroup into essential and non-essential human cell categories; the width of the bands is proportional to the number of genes. b Gene Ontology Biological Process (GO BP) enrichment results. Significantly enriched GO terms at the biological process level were computed using the set of IMPC mouse-to-human orthologues incorporated into the FUSIL categories as a reference (Table 1) and identified after correcting for multiple comparisons. Significant results were only found for the cellular and developmental lethal gene categories. Bubble size is proportional to the frequency of the term in the database and the colour indicates significance level as obtained in the enrichment analysis. The GO terms associated with embryo development are in bold. c Correspondence between mouse embryonic lethality stage and essentiality in human cell lines. Embryonic lethal LoF strains are assessed for viability at selected stages during embryonic development: early (gestation) lethal (prior to E9.5), mid (gestation) lethal (E9.5–E14.5/15.5), late (gestation) lethal (E14.5/E15.5 onwards). E embryonic day.