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. 2020 Jan 31;10:1615. doi: 10.1038/s41598-020-58365-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Statistically significant regions of t-distribution of delta-band current sources before pLM or iLM onset versus baseline (FDR correction, FDR-adjusted p value < 0.005) were demonstrated. (A) The significant regions at −4~−3 seconds before pLM onset were right pericentral, bilateral dorsolateral, and cingulate regions compared to the baseline interval, and (B) spreads diffusely over fronto-temporal lobes at −3~−2 seconds. (C) In contrast, the significant regions were sparsely observed at −4~−3 seconds before iLM onset. (D) At −3~−2 seconds before iLM onset, the significant regions were mainly in the right pericentral and left parieto-occipital areas. Abbreviations: pLM, LM belonging to PLMS; iLM, LM not belonging to PLMS; LM, leg movement; PLMS, periodic leg movements during sleep; FDR, false discovery rate.