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. 2020 Jan 25;7:188–197. doi: 10.1016/j.toxrep.2020.01.008

Table 2.

Summary of Cmax and Tmax of treatment groups.

Group Cmax (ng/ml) Tmax (min)
Oxycodone PK 6.75 mg/kg 7.0 30
60 mg/kg* 35.3 54
150 mg/kg** 51.5 30
Diazepam PK 2 mg/kg 22.6 30
20 mg/kg 286.5a 18a
200 mg/kg** 1370.9 132
Oxycodone PK, repeat 60 mg/kg 25.0 48
Oxycodone PK, repeat 150 mg/kg 45.0 78
Oxycodone 150 mg/g + Diazepem 20 mg/kg Combined oxycodone* 102.3a 78a
diazepam 134.3a 48a
Oxycodone (control) 51.2a 66a

*p < 0.05, **P < 0.001: post treatment blood drug concentrations when compared with the lowest doses for PK studies; or when compared with controls for the combination study.

a

see reference [34].