Table 2.
Summary of Cmax and Tmax of treatment groups.
| Group | Cmax (ng/ml) | Tmax (min) | ||
|---|---|---|---|---|
| Oxycodone PK | 6.75 mg/kg | 7.0 | 30 | |
| 60 mg/kg* | 35.3 | 54 | ||
| 150 mg/kg** | 51.5 | 30 | ||
| Diazepam PK | 2 mg/kg | 22.6 | 30 | |
| 20 mg/kg | 286.5a | 18a | ||
| 200 mg/kg** | 1370.9 | 132 | ||
| Oxycodone PK, repeat | 60 mg/kg | 25.0 | 48 | |
| Oxycodone PK, repeat | 150 mg/kg | 45.0 | 78 | |
| Oxycodone 150 mg/g + Diazepem 20 mg/kg | Combined | oxycodone* | 102.3a | 78a |
| diazepam | 134.3a | 48a | ||
| Oxycodone (control) | 51.2a | 66a | ||
*p < 0.05, **P < 0.001: post treatment blood drug concentrations when compared with the lowest doses for PK studies; or when compared with controls for the combination study.
see reference [34].