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. 2020 Jan 24;9(1):bio047662. doi: 10.1242/bio.047662

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — P780-Y781 ERBB2 enhances colony-formation ability and but does not impact cell apoptosis. (A) Mutant ERBB2 dramatically elevated the colony counts. Typical photos of colony staining of three groups under vehicle, lapatinib, perifosine and lapatinib+perifosine. (B) The colony counts in the ERBB2-NC and ERBB2-WT groups. ERBB2-MT dramatically elevated the colony counts in comparison with WT (t=7.01, P<0.05). However, under both lapatinib and perifosine stress, colony formation ability in the ERBB2-MT group and ERBB2-WT group were similar. (C) Three groups of cells showed similar apoptosis levels at normal condition and under lapatinib stress (F=4.05, P>0.05).