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. 2020 Jan 10;13(2):dmm040659. doi: 10.1242/dmm.040659

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Bone parameters in muscular dystrophy mouse models. (A) Representative µCT images of tibial bone of all genotypes at 3, 5 and 7 weeks of age to show bone development (upper row, mid diaphyseal cortical bone; lower row, metaphyseal trabecular bone). (B) Compared to similarly aged WT mice, cortical bone fraction was lower in mdx:Cmah⁻^/− mice at 3 weeks of age, but higher in all muscular dystrophy models at 7 weeks of age. (C) Cortical tissue mineral density was higher in mdx:Cmah⁻^/− mice at 3 and 7 weeks of age and in mdx:Utrn^+/− (shown as mdx:utr in the figure) mice at 5 weeks when compared to WT mice. (D) Trabecular tissue volume was lower in mdx:Cmah⁻^/− mice at 3 and 7 weeks of age compared with WT. (E) Trabecular connectivity was lower in mdx:Utrn^+/− mice at 5 weeks and mdx:Cmah⁻^/− mice at both 5 and 7 weeks when compared to WT mice. (F,G) The number of osteoblasts (F; N.Ob/BS) and osteoclasts (G; N.Oc/BS) per bone surface were normal in all muscular dystrophy models at 5 weeks of age. Data are presented are mean±s.d. (n>6); *P<0.05, **P<0.01, ***P<0.001 compared to WT mice.