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. 2020 Jan 13;13(1):dmm043281. doi: 10.1242/dmm.043281

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Analysis of PTC sequences with positive and negative read-through induction. (A) Multiple Alignment using Fast Fourier Transform (MAFFT) of 30 sequences with described positive read-through induction. (B) MAFFT alignment of 29 sequences with reported absence read-through induction. Orange arrows mark highly conserved nucleotides (>70% for the combination of two nucleotides and ≥50% for a single nucleotide) among the aligned sequences. (C) Consensus sequence obtained from the 30 sequences with described read-through induction. (D) Consensus sequence obtained from the 29 sequences with reported absence of read-through induction. (E) Mouse Pygm PTC context sequence. Potentially relevant nucleotides for read-through induction are squared.