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. 2020 Jan 14;117(4):2149–2159. doi: 10.1073/pnas.1909915117

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Fig. 2. — Alcohol drinking and abstinence behavior in alcohol-dependent vs. control mice. (A) Alcohol-dependent mice (black bars) exhibited a significant increase in alcohol drinking during postvapor week-5 2BC testing compared with alcohol drinking in nondependent mice (white bars) and their own baseline intake. (B) Irritability-like behavior. Alcohol-dependent mice (black bar) exhibited a significant increase in total irritable-like responses compared with control mice (nondependent and naive; white bar). (C) Digging behavior. Alcohol-dependent mice (black bar) exhibited a significant increase in composite digging behavior (Z-score of digging behaviors) compared with control mice (nondependent and naive; white bar). *P < 0.05 (two-tailed), alcohol-dependent vs. nondependent for alcohol drinking or control for irritability-like and digging behavior; ^#P < 0.05 (two-tailed), alcohol-dependent postvapor week 5 vs. alcohol-dependent baseline.