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The base pairing ability of the 23S rRNA residues 752 and 2609 impacts the bactericidal properties of SOL. (A) Concentration dependence of SOL cidality after 4 h drug exposure. (B) Time dependence of the cidal effect of 4× MIC of SOL. (C) Cell survival after 4 h treatment with 7× MIC of ERY (gray bars) or SOL (black bars). Error bars represent SD of three independent replicates.
