Fig. 4.

Network and heatmap analysis of miR166/165 and their targets. (A) Network of miRNA166/165 family members (magenta) and their targets (green). (B) Inverse correlation between the expression of miRNAs and that of their target genes in VC20, VC200, and VC600. The heatmaps are color coded by expression ratios [log₂(VC20_mean/VC20_mean), log₂(VC200_mean/VC20_mean), log₂ (VC600_mean/VC20_mean)]; blue, lower expression; red, higher expression. (C) Target plots show signature abundance at the positions of target transcripts identified by degradome sequencing. Red lines, signatures corresponding to miRNA cleavage sites.