Fig. 2.
Correlation of hyperpolarized 13C MRI data with tumor volume and expression of the MCT1 and HIF1α. (A) Each patient is represented by an individual point, with the size of each circle proportional to the respective tumor size. (B and C) Correlation of LAC/PYR and summed SNRLAC with tumor volume. (D−G) Correlation of LAC/PYR and summed SNRLAC with expression of MCT1, determined by both (D and E) IHC and (F and G) RNA sequencing. (H and I) Correlation of LAC/PYR and summed SNRLAC with expression of HIF1α determined by RNA sequencing. Abbreviations: IHC [% pos tissue], percentage of formalin fixed paraffin embedded tissue positive for IHC staining; RNAseq, normalized expression based on RNA sequencing.